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Crystal Structure of CD180/MD-1 Complex

CD180 has attributes of Toll-Like-Receptors, and it recognizes mycobacterial lipoproteins


CD180 is exclusively expressed on two classes of antigen-presenting cells (APCs), B Cells and Dendritic Cells


Activating anti-CD180 mAbs signal immune cells to initiate and program robust Antigen-Specific Immune Responses

Image Source: https://www.rcsb.org/3d-sequence/3B2D?assemblyId=1 

Antigen-Specific Immune Accelerant (A.S.I.A.)

Physical coupling of the CD180 binding domain and antigen programs APCs for active immunotherapeutic responses


Opportunities to combine with existing therapeutic modalities to further improve clinical outcomes

Easily Tractable Protein Engineering


Modularity & Flexibility


Custom designs to deliver Different Antigens or Combinations of Different Antigens 

Literature

Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway


Jay W Chaplin, Shinji Kasahara, Edward A Clark, Jeffrey A Ledbetter

PubMed

Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory


Jay W Chaplin, Craig P Chappell, Edward A Clark

PubMed

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization


Daniela Giordano, Kevin E Draves, Lucy B Young, Kelsey Roe, Marianne A Bryan, Christiane Dresch, Justin M Richner, Michael S Diamond, Michael Gale Jr, Edward A Clark

PubMed

Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs


Kelsey Roe, Geraldine L Shu, Kevin E Draves, Daniela Giordano, Marion Pepper, Edward A Clark

PubMed

A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza


Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura

PubMed

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