Crystal Structure of CD180/MD-1 Complex
CD180 has attributes of Toll-Like-Receptors, and it recognizes mycobacterial lipoproteins
CD180 is exclusively expressed on two classes of antigen-presenting cells (APCs), B Cells and Dendritic Cells
Activating anti-CD180 mAbs signal immune cells to initiate and program robust Antigen-Specific Immune Responses
Image Source: https://www.rcsb.org/3d-sequence/3B2D?assemblyId=1
Antigen-Specific Immune Accelerant (A.S.I.A.)
Literature
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway
Jay W Chaplin, Shinji Kasahara, Edward A Clark, Jeffrey A Ledbetter
Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory
Jay W Chaplin, Craig P Chappell, Edward A Clark
Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization
Daniela Giordano, Kevin E Draves, Lucy B Young, Kelsey Roe, Marianne A Bryan, Christiane Dresch, Justin M Richner, Michael S Diamond, Michael Gale Jr, Edward A Clark
Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs
Kelsey Roe, Geraldine L Shu, Kevin E Draves, Daniela Giordano, Marion Pepper, Edward A Clark
A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza
Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura